Calcium Therapy in Diseases of the Cardiovascular System
نویسنده
چکیده
About fifty years ago Ringer demonstrated experimentally in a striking way that sodium, calcium and potassium were essential for the contraction of the heart muscle. He found that when the concentration of potassium was increased in the solution in which the heart was immersed the contractions decreased, and if the concentration was further increased the contractions became weaker and weaker, the heart finally stopping in diastole and failing to respond to any further electrical stimulation. On the other hand if calcium was added to the solution, the response to stimulation reappeared and spontaneous contractions became stronger, the intervals between them lengthened and the heart finally stopped in a state of tonic contraction, a systolic standstill termed calcium rigor.
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